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KMID : 0384320070280110860
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Korean Journal of Family Medicine
2007 Volume.28 No. 11 p.860 ~ p.866
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The Relationship between Reduced Lung Function and High Sensitive C-reactive Protein in Healthy Adult Men
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Lee Jung-Woon
Paek Yu-Jin
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Abstract
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Background: Increased levels of systemic markers of inflammation have been reported in patients with impaired lung function with obstructive and restrictive lung diseases. We hypothesized that forced expiratory volume in 1 second (FEV1) within the normal range is inversely associated with high sensitive C-reactive protein (hs-CRP), as a marker of chronic inflammation in healthy Korean adult men.
Methods: We analyzed the association of hs-CRP with pulmonary function test including FEV1, components of
metabolic syndrome among male participants (n=3,736), more than 20 years old who had visited a health promotion
center at a university hospital between January and December, 2006.
Results: In this cross-sectional study, there was an inverse association between hs-CRP levels and quartiles of FEV1 (P for trend＜0.0001) after adjusting for age, smoking status, waist circumference, glucose, triglyceride, and
HDL-cholesterol. A similar association was present in non-smoking subjects, but there was no significant trend (P for trend=0.115) whereas it was significant in smoking subjects (P for trend＜0.0001), and in ex-smoking subjects (P for trend=0.006). The odds ratios of having elevated hs-CRP (＞2.2 mg/L) across FEV1 quartiles, with the lowest quartile (Q1) as the reference group was 1.01 (0.75 ∼1.35) in Q2, 1.24 (0.93∼1.65) in Q3, 1.52 (1.15∼2.01) in Q4 after adjusting for the confounding variables.
Conclusion: The decline of FEV1 within the normal range was inversely associated with low grade inflammation as measured by hs-CRP. This result showed that systemic inflammation may be linked to early impaired pulmonary
function in healthy adult men.
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KEYWORD
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high sensitive C-reactive protein, forced expiratory volume, respiratory function tests, systemic inflammation, male
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